Von Willebrand Disease

Von Willebrand Disease (VWD) is a bleeding disorder which affects blood clotting. Affected dogs may have nosebleeds and bruise easily, as well as bleed heavily after injury or surgery. Most dogs will have a normal life expectancy but this condition should be noted to veterinarians in the case of surgery.

An autosomal recessive condition caused by a mutation in the VWF gene.

Brooks MB, Erb HN, Foureman PA, Ray K. von Willebrand disease phenotype and von Willebrand factor marker genotype in Doberman Pinschers. Am J Vet Res. 2001 Mar;62(3):364-9

Vos-Loohuis M, van Oost BA, Dangel C, Langbein-Detsch I, Leegwater PA. A novel VWF variant associated with type 2 von Willebrand disease in German Wirehaired Pointers and German Shorthaired Pointers. Anim Genet. 2017 Aug;48(4):493-496

Pathak EJ. Type 3 von Willebrand's disease in a Shetland sheepdog. Can Vet J. 2004 Aug;45(8):685-7