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I-Locus (intensity)

Original price £42.00 - Original price £42.00
Original price
£42.00 - £42.00
Current price £42.00

The I-Locus is a region of your dog's DNA which controls the intensity of colour of the phaeomelanin or yellow/red pigment which is expressed through the E-locus.

Your dog's coat colour intensity will only be affected if your dog is e/e on the E-Locus and thus expressing the yellow coat pigment.

The coat colour intensity is affected by mutations on the MFSD12 gene.


Your results will be reported as one combination of the I-locus alleles with the following interpretations.

I/I - higher intensity - yellow/red
I/i - higher intensity - yellow/red
i/i - reduced intensity - cream/white


Scientific references:

Hédan B, Cadieu E, Botherel N, Dufaure de Citres C, Letko A, Rimbault M, Drögemüller C, Jagannathan V, Derrien T, Schmutz S, Leeb T, André C. Identification of a Missense Variant in MFSD12 Involved in Dilution of Phaeomelanin Leading to White or Cream Coat Color in Dogs. Genes (Basel). 2019 May 21;10(5):386