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Haemophilia

Haemophilia

Turnaround: 1-2 weeks

£48.00 - £48.00
£48.00
£48.00 - £48.00
£48.00

Haemophilia (FD), or Coagulation Factor Deficiency, is a disorder which affects normal blood clotting and causes haemophilia. Affected dogs can have a normal life, but it should be noted in case of trauma or surgery which could cause excessive bleeding.

An autosomal recessive condition caused by a mutation in the F7 gene (Factor VII Deficiency), or an X-linked recessive condition caused by a mutation in the F8 (Haemophilia A) or F9 (Haemophilia B) gene.

Description

Scientific references

Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U, High KA. A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. J Thromb Haemost. 2006 Dec;4(12):2616-22

Christopherson PW, Bacek LM, King KB, Boudreaux MK. Two novel missense mutations associated with hemophilia A in a family of Boxers, and a German Shepherd dog. Vet Clin Pathol. 2014 Sep;43(3):312-6