Cobalamin Malabsorption

Cobalamin Malabsorption or Imerslund-Grasbeck Syndrome (IGS) is an inability of the intestine to properly absorb B12 which is needed for cell growth and in the nervous system. Early signs include a loss of appetite and energy, and abnormal growth.

Imerslund-Grasbeck Syndrome is an autosomal recessive condition caused by a mutation in the CUBN gene.

Kather S, Grützner N, Kook PH, Dengler F, Heilmann RM. Review of cobalamin status and disorders of cobalamin metabolism in dogs. J Vet Intern Med. 2020 Jan;34(1):13-28

He Q, Fyfe JC, Schäffer AA, Kilkenney A, Werner P, Kirkness EF, Henthorn PS. Canine Imerslund-Gräsbeck syndrome maps to a region orthologous to HSA14q. Mamm Genome. 2003 Nov;14(11):758-64