The I-Locus is a region of your dog's DNA which controls the intensity of colour of the phaeomelanin or yellow/red pigment which is expressed through the E-locus.
Your dog's coat colour intensity will only be affected if your dog is e/e on the E-Locus and thus expressing the yellow coat pigment.
The coat colour intensity is affected by mutations on the MFSD12 gene.
Your results will be reported as one combination of the I-locus alleles with the following interpretations.
|I/I||- higher intensity - yellow/red|
|I/i||- higher intensity - yellow/red|
|i/i||- reduced intensity - cream/white|
Hédan B, Cadieu E, Botherel N, Dufaure de Citres C, Letko A, Rimbault M, Drögemüller C, Jagannathan V, Derrien T, Schmutz S, Leeb T, André C. Identification of a Missense Variant in MFSD12 Involved in Dilution of Phaeomelanin Leading to White or Cream Coat Color in Dogs. Genes (Basel). 2019 May 21;10(5):386