Foresight Health® Severe Combined Immunodeficiency Disease

Our Foresight Health® single test for Severe Combined Immunodeficiency Disease is ideal for breeders and owners who want the reassurance of genetic health testing.

The guideline turnaround time for single tests is approximately 10-12 working days after the swab arrives at the lab. 

If you need more than two tests it is often more cost-effective to order the relevant Foresight Health^® breed package.

Description

Severe Combined Immunodeficiency Disease (SCID) is an immune problem as a result of inability to produce a certain protein needed. Affected dogs suffer from severe fungal, viral, and bacterial infections causing poor growth, weight loss, vomiting, and diarrhoea. Affected dogs often die within four months of birth.

An autosomal recessive condition caused by a mutation in the PRKCD gene or an X-linked recessive condition caused by a mutation in the IL2RG gene.

Breeds

This test is also included in the following Foresight Health^® breed packages:

• Basset Hound  (X-linked Basset Type)
• Jack Russell Terrier  (Autosomal)
• Parson Russell Terrier  (Autosomal)
• Welsh Corgi Cardigan  (X-linked Corgi Type)

Scientific references:

Bell TG, Butler KL, Sill HB, Stickle JE, Ramos-Vara JA, Dark MJ. Autosomal recessive severe combined immunodeficiency of Jack Russell terriers. J Vet Diagn Invest. 2002 May;14(3):194-204

Pullen RP, Somberg RL, Felsburg PJ, Henthorn PS. X-linked severe combined immunodeficiency in a family of Cardigan Welsh corgis. J Am Anim Hosp Assoc. 1997 Nov-Dec;33(6):494-9