Foresight Health® Primary Open Angle Glaucoma

£42.00

Our Foresight Health® single test for Primary Open Angle Glaucoma is ideal for breeders and owners who want the reassurance of genetic health testing.

Our DNA test results are accepted by the Kennel Club.

Description

Primary Open Angle Glaucoma (POAG) is an eye condition causing increased pressure in the eyes, causing enlargement and pain. If left untreated this can lead to nerve damage and vision loss.

An autosomal recessive condition caused by a mutation in the ADAMTS17 or ADAMTS10 gene.

Breeds

This test is also included in the following Foresight Health® breed packages:

 

The guideline turnaround time for single tests is approximately 10-12 working days after the swab arrives at the lab. 

If you need more than two tests it is often more cost-effective to order the relevant Foresight Health® breed package.

 

Scientific references:

Oliver JAC, Rustidge S, Pettitt L, Jenkins CA, Farias FHG, Giuliano EA, Mellersh CS. Evaluation of ADAMTS17 in Chinese Shar-Pei with primary open-angle glaucoma, primary lens luxation, or both. Am J Vet Res. 2018 Jan;79(1):98-106

Kuchtey J, Kunkel J, Esson D, Sapienza JS, Ward DA, Plummer CE, Gelatt KN, Kuchtey RW. Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in beagles. Invest Ophthalmol Vis Sci. 2013 Mar 13;54(3):1881-6

Bedford PG. Open-angle glaucoma in the Petit Basset Griffon Vendeen. Vet Ophthalmol. 2017 Mar;20(2):98-102

Oliver JA, Forman OP, Pettitt L, Mellersh CS. Two Independent Mutations in ADAMTS17 Are Associated with Primary Open Angle Glaucoma in the Basset Hound and Basset Fauve de Bretagne Breeds of Dog. PLoS One. 2015 Oct 16;10(10):e0140436

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