Foresight Health® Osteogenesis Imperfecta
Our Foresight Health® single test for Osteogenesis Imperfecta is ideal for breeders and owners who want the reassurance of genetic health testing.
The guideline turnaround time for single tests is approximately 10-12 working days after the swab arrives at the lab.
If you need more than two tests it is often more cost-effective to order the relevant Foresight Health® breed package.
Osteogenesis Imperfecta (OI) is a collagen disorder starting at a few weeks of age. It causes lameness and fractures due to thinner than normal bones, as well as loose joints and brittle teeth. Affected dogs are usually euthanised at a young age.
An autosomal recessive condition caused by a mutation in the SERPINH1 or an autosomal dominant condition caused by a mutation in the COL1A1 gene.
This test is also included in the following Foresight Health® breed packages:
- Golden Retriever (Golden Retriever Type)
- Goldendoodle (Golden Retriever Type)
- Miniature Long Haired Dachshund (Dachshund Type)
- Miniature Short Haired Dachshund (Dachshund Type)
- Miniature Wire Haired Dachshund (Dachshund Type)
Lindert U, Weis MA, Rai J, Seeliger F, Hausser I, Leeb T, Eyre D, Rohrbach M, Giunta C. Molecular Consequences of the SERPINH1/HSP47 Mutation in the Dachshund Natural Model of Osteogenesis Imperfecta. J Biol Chem. 2015 Jul 17;290(29):17679-17689
Campbell BG, Wootton JA, MacLeod JN, Minor RR. Sequence of normal canine COL1A1 cDNA and identification of a heterozygous alpha1(I) collagen Gly208Ala mutation in a severe case of canine osteogenesis imperfecta. Arch Biochem Biophys. 2000 Dec 1;384(1):37-46