Foresight Health® Juvenile Laryngeal Paralysis and Polyneuropathy

Our Foresight Health® single test for Juvenile Laryngeal Paralysis and Polyneuropathy is ideal for breeders and owners who want the reassurance of genetic health testing.

The guideline turnaround time for single tests is approximately 10-12 working days after the swab arrives at the lab. 

If you need more than two tests it is often more cost-effective to order the relevant Foresight Health^® breed package.

Description

Juvenile Laryngeal Paralysis and Polyneuropathy (JLPP) is a progressive neurological disease beginning in the first few months of life. It causes vocal cord paralysis, respiratory distress, limb weakness and numbness, and abnormal gait, being fatal early in life.

An autosomal recessive condition caused by a mutation in the RAB3GAP1 gene.

Breeds

This test is also included in the following Foresight Health^® breed packages:

• Rottweiler
• Russian Black Terrier

Scientific references:

Mhlanga-Mutangadura T, Johnson GS, Ashwini A, Shelton GD, Wennogle SA, Johnson GC, Kuroki K, O'Brien DP. A Homozygous RAB3GAP1:c.743delC Mutation in Rottweilers with Neuronal Vacuolation and Spinocerebellar Degeneration. J Vet Intern Med. 2016 May;30(3):813-8

Mhlanga-Mutangadura T, Johnson GS, Schnabel RD, Taylor JF, Johnson GC, Katz ML, Shelton GD, Lever TE, Giuliano E, Granger N, Shomper J, O'Brien DP. A mutation in the Warburg syndrome gene, RAB3GAP1, causes a similar syndrome with polyneuropathy and neuronal vacuolation in Black Russian Terrier dogs. Neurobiol Dis. 2016 Feb;86:75-85