Foresight Health® Gangliosidosis
Our Foresight Health® single test for Gangliosidosis is ideal for breeders and owners who want the reassurance of genetic health testing.
Our DNA test results are accepted by the Kennel Club.
Gangliosidosis (GM) is a lysosomal storage disease which affects an enzyme during metabolism. Around two to six months of age the signs begin, with limb weakness, balance problem, weight loss, head tremors, and rapid progression to death at a young age.
An autosomal recessive condition caused by a mutation in the GLB1 (GM1) or HEXB (GM2) gene.
This test is also included in the following Foresight Health® breed packages:
- Cavapoo (Type 2)
- Cockapoo (Type 2)
- Goldendoodle (Type 2)
- Irish Doodle (Type 2)
- Japanese Shiba Inu (Type 1-Shiba Inu, Type 2-Shiba Inu)
- Labradoodle (Type 2)
- Poodle Miniature (Type 2)
- Poodle Standard (Type 2)
- Poodle Toy (Type 2)
- Portuguese Water Dog (Type 1)
- Schnoodle (Type 2)
- Sheepadoodle (Type 2)
The guideline turnaround time for single tests is approximately 10-12 working days after the swab arrives at the lab.
If you need more than two tests it is often more cost-effective to order the relevant Foresight Health® breed package.
Chang HS, Arai T, Yabuki A, Hossain MA, Rahman MM, Mizukami K, Yamato O. Rapid and reliable genotyping technique for GM1 gangliosidosis in Shiba dogs by real-time polymerase chain reaction with TaqMan minor groove binder probes. J Vet Diagn Invest. 2010 Mar;22(2):234-7