Foresight Health® Dog
- Included tests: Blood and Heart
- Included tests: Dental
- Included tests: Drug Response
- Included tests: Eye
- Included tests: Hormonal
- Included tests: Immune system
- Included tests: Metabolic
- Included tests: Muscle
- Included tests: Nervous system
- Included tests: Neuromuscular
- Included tests: Reproductive
- Included tests: Respiratory
- Included tests: Skeletal
- Included tests: Skin
- Included tests: Urinary
- Optional: A-Locus (for fawn/sable, agouti, black and tan, recessive black)
- Optional: B-Locus (for brown, liver, red and chocolate)
- Optional: D-Locus (for dilute coat colour)
- Optional: E-Locus (for extension) and Em-Locus (for melanistic mask)
- Optional: K-Locus (for dominant black)
- Optional: H-Locus (for harlequin)
- Optional: M-Locus (for Merle)
- Optional: S-Locus (for piebald, pied, white spotting)
- Optional: Saddle Tan
- Optional: T-Locus (for natural bobtail)
- Optional: Furnishings
- Optional: Cu-Locus (for curly coat)
- Optional: L-Locus (for long coat)
- Optional: SD-Locus (for shedding)
The results of DNA testing with Foresight Health are accepted by The Kennel Club
Our proprietary next-generation testing method tests each mutation thousands of times to ensure accuracy while making DNA testing more affordable than ever.
- If you want to check which inherited diseases in Foresight Health are applicable to your breed, please use the search bar to find the DNA testing guide for your breed.
- Looking for colour testing too? Choose to add 14 coat colours and traits to your health testing for only an extra £49! We include the following locus tests: A (fawn, tan points, sable, recessive black), B (chocolate, brown), D (dilute), E (yellow, red, cream), Em (melanistic mask), H (harlequin), K (dominant black), S (pied, piebald), T (bobtail), Curly coat, long coat, furnishings/improper coat, Merle and shedding.
- Foresight Health covers the DNA tests currently required for breed testing schemes offered by the Kennel Club (search for your breed to find out more).
- We want to make sure your DNA testing experience is simple yet high quality. The expert geneticists who developed our advanced DNA tests are available for any questions you may have.
How long does it take?
We aim to turn around Foresight Health samples in 15 working days from when the swab arrives back at the lab. However, this is a guideline turnaround and while it can sometimes be a few days quicker, it can also be a few days slower, depending on how busy the lab is. Our next-generation testing methods take a little longer than the older methods used by other labs but we believe that good things are worth waiting for.
What happens when I order?
We will send you out one of our eco-friendly (and totally recyclable) kits for swabbing your dog's cheek to collect DNA. You activate your kit on our website and send the swab back to us. We begin testing your dog's DNA and you'll be kept updated by our online system and by email as the testing progresses. Once your results are ready you'll be able to see them in a fantastic interactive report on our dedicated results site.
- Coagulation Factor VII deficiency (F7)
- Phosphofructokinase deficiency (PFKD)
- Coagulation Factor VIII Deficiency (Haemophilia A)
- Canine Leucocyte Adhesion Deficiency Type I (CLAD)
- Malignant Histiocytosis
- Prekallikrein deficiency (KTK)
- Pyruvate kinase deficiency (PKDef)
- Arrythmogenic Right Ventricular Cardiomyopathy (ARVC)
- Glanzmann's Thrombasthenia Type I
- Congenital Macrothrombocytopaniea
- Von Willebrand disease I (vWD1)
- Von Willebrand disease II (vWD2)
- Von Willebrand disease III (vWD3)
- Canine Scott Syndrome
- Trapped Neutrophil Syndrome (TNS)
- Coagulopathy P2RY12-related
- May-Hegglin anomaly
- Amelogenesis Imperfecta (AI)
- Dental hypomineralisation
- Malignant hyperthermia (MH)
- Achromatopsia (Cone Degeneration, originally discovered in Alaskan Malamute)
- Achromatopsia (Cone Degeneration, Hemeralopia, originally discovered in the German Shorthaired Pointer)
- Achromatopsia 2
- Bardet-Biedle syndrome 4 (PRA in Puli)
- Canine Multifocal Retinopathy 1 (CMR1)
- Canine Multifocal Retinopathy 2 (CMR2)
- Canine Multifocal Retinopathy 3 (CMR3)
- Juvenile Hereditary Cataracts (JHC, Early onset Cataracts)
- Macular corneal dystrophy
- Primary Lens Luxation (PLL)
- Primary Open Angle Glaucoma (POAG, originally discovered in Beagle)
- Primary Open Angle Glaucoma (POAG, originally discovered in Basset Hound)
- Progressive Retinal Atrophy
- CNGB1 variant (Papillon)
- SAG variant (Basenji)
- CNGA1 variant (Shetland Sheepdog)
- GRPRA2 variant (Golden Retriever)
- Autosomal Dominant
- cone-rod dystrophy 1 (crd1)
- cone-rod dystrophy 2 (crd2)
- rod-cone dysplasia (rcd1)
- rod-cone dysplasia (rcd1a)
- rod-cone dysplasia (rcd3)
- Congenital Hypothyroidism
- Complement 3 (C3) deficiency
- Cyclic Neutropaenia (CN, Gray Collie Syndrome)
- Severe Combined Immunodeficiency (PRKDC variant)
- Severe Combined Immunodeficiency (RAG1 variant)
- X-linked Severe Combined Immunodeficiency
- Cobalamin malabsorption
- Gallbladder mucoceles
- Glycogen Storage Disease Ia (Von Gierke Disease)
- Glycogen Storage Disease II (Pompe's Disease)
- Glycogen Storage Disease IIIa
- Imerslund-Grasbeck Syndrome (IGS, Cobalamin malabsorption)
- Labrador obesity susceptibility
- Lagotto Storage Disease
- Lundehund syndrome
- Menke's disease
- Mucopolysaccharidosis I
- Mucopolysaccharidosis IIIA
- Mucopolysaccharidosis VI
- Mucopolysaccharidosis VII
- Periodic Fever Syndrome
- Pyruvate dehydrogenase deficiency
- Wilson's Disease (Copper toxicosis)
- Inherited myopathy of Great Danes
- Muscular Dystrophy
- Muscular hypertrophy (Bully whippet syndrome)
- Myotonia Congenita
- Myotubular myopathy 1
- Nemaline myopathy
- Acral Mutilation Syndrome
- Alaskan Husky Encephalopathy (Subacute nectrotising encephalopathy of Leigh)
- Alexander disease
- Axonal Disease Hypomyelination and Tremor
- Benign Familiar Juvenile Epilepsy
- Cerebellar Ataxia (RAB24 variant)
- Cerebellar Ataxia (KCNJ10 variant)
- Cerebellar Ataxia (ATP1B2 variant)
- Cerebellar cortical degeneration
- Deafness and vestibular dysfunction
- Foetal-onset / neonatal neuroaxonal dystrophy
- Generalised myoclonic epilepsy with photosensitivity
- Juvenile euroaxonal dystrophy
- L-2-hydroxyglutaricaciduria (L-2-HGA)
- Leonberger Polyneuropathy
- Neonatal Ataxia (NA, Bandera's Neonatal Ataxia, BNAt)
- Neonatal Encephalopathy with seizures (NEWS)
- Neuroaxonal dystrophy (PLA2G6 variant)
- Neuroaxonal dystrophy (VPS11 variant)
- Neuronal Ceroid Lipofuscinosis (NCL) variants 1, 10, 12, 2, 4A, 6, 7 and 8
- Sensory Ataxic Neuropathy (SAN)
- Shaking puppy syndrome (X-linked generalised tremor syndrome)
- Spinocerebellar Ataxia (KCNJ10 variant - Late Onset Ataxia)
- Congenital myasthenic syndrome (CMS, CHRNE variant)
- Congenital myasthenic syndrome (CMS, COLQ variant)
- Congenital myasthenic syndrome (CMS, CHAT variant)
- Exercise-induced metabolic myopathy
- Gangliosidosis GM1
- Gangliosidosis GM2 (HEXA variant)
- Gangliosidosis GM2 (HEXB variant)
- Globoid Cell Leukodystrophy (Krabbe's Disease)
- Greyhound Polyneuropathy
- Muscular Dystrophy (Limb-girdle type 2F)
- Paroxysmal Dyskenesia
- BTBD17-related embryonic lethality
- Persistent Mullerian Duct Syndrome
- Primary Ciliary Dyskinesia
- Acute Respiratory Distress Syndrome (ARDS)
- Craniomandibular osteopathy
- Hereditary Vitamin D-resistant rickets
- Musladin-Lueke syndrome (MLS)
- Osteogeneisis Imperfecta (3 variants)
- Skeletal dysplasia
- Spondylocostal dysostosis
- Albinism (OCA2 and SLC45A2 variants)
- Anhidrotic Ectodermal Dysplasia
- Dry Eye Curly Coat Syndrome
- Dystrophic epidermolysis bullosa
- Ectodermal dysplasia
- Epidermolytic Hyperkeratosis
- Focal non-epidermolytic palmoplantar keratoderma
- Lethal acrodermatitis
- Ligneous membranitis
- Palmoplantar hyperkeratosis (Hereditary footpad keratosis)
- Recessive Hypotrichosis
- Cystinuria Type I-A
- Cystinuria Type II-A
- Cystinuria Type II-B
- Familial Nephropathy (FN)
- Hyperuricosuria (HUU)
- Primary Hyperoxaluria
- Renal Cystadenocarcinoma and Nodular Dermatofibrosis
- X-linked nephropathy
The A-locus is a region of your dog's DNA that codes for a protein that causes your dog's hair follicles to produce a reddish yellow pigment called phaeomelanin instead of a black or brown pigment called eumelanin.
The region has four alleles which have a dominance hierarchy:
This means that fawn/sable (ay) is dominant over wolf-like fur (aw), which is dominant over black and tan (at), which is dominant over recessive black (a).
This is one of the most common alleles in dogs. Dogs carrying an ay allele are uniformly yellow (referred to as fawn, tan, or sable), though the tips of the hairs are often black.
This is the ancestral allele (a.k.a. wild type, or agouti) which causes some hairs to have alternating bands of eumelanin and phaeomelanin from root to tip.
Black and tan (at)
This allele gives your dog a characteristic look with a black body but yellow (or tan) markings on the head, legs and feet (black and tan).
Recessive black (a)
This allele is the lowest in the dominance hierarchy and is known as recessive because a dog needs to have two copies of it to produce a fully black dog. This is a lesser cause of fully black dogs as most are caused by a dominant allele in the K-Locus. The recessive black allele (a) is the cause of fully black German Shepherds and Shetland Sheepdogs.
- Berryere TG, Kerns JA, Barsh GS and Schmutz SM (2005). Association of an Agouti allele with fawn or sable coat colour in domestic dogs. Mamm Genome 16, 262-272
- Kerns JA, Newton J, Berryere TG, Rubin EM, Cheng JF, Schmutz SM and Barsh GS (2004). Characterisation of the dog Agouti gene and a nonagoutimutation in German Shepherd dogs. Mamm Genome 15, 798-808
- Schmutz SM and Berryere TG (2007) Genes affecting coat colour and pattern in domestic dogs: a review. Anim. Genet. 38, 539-549.
The B-Locus is a region of your dog's DNA which controls whether your dog has a brown coat colour. The region produces a protein which alters the colour of of your dog's coat and skin.
There are three alleles (a.k.a. mutations) present in the B-locus which cause your dog's coat colour to be brown, if your dog has inherited any two of them: bs, bd and bc. The wild type black coat colour is present if no copies of bs, bd or bc are present (BB), or if only one copy of either bs, bd or bc are present (Bb). If your dog only has one copy of bs, bd or bc, then they carry brown and have the potential to produce brown puppies if mated with a Bb or bb dog.
In some breeds, such as the Dobermann and Australian Shepherd, brown dogs are referred to as red.
The B-locus is a good example of the interactions between the coat colour genes. Your dog can only be brown if they are bb at the B-locus and also Ee or EE at the E-locus.
The D-locus is a region of your dog's DNA which controls whether your dog will have a diluted coat colour. In some breeds like this is known as blue, lilac or isabella. In dilute dogs, their eyes will also lighten to an amber colour.
The D-locus allele which causes a diluted coat colour (d) is recessive, which means a dog has to inherit two copies (dd) for the coat colour to be dilute. Dogs which carry one copy of dilute (Dd) can produce dilute puppies if they are bred to a Dd or dd dog. If your dog does not carry any copies of dilute (DD) they don't have a dilute coat and can't pass it on to their puppies.
The dilute coat colour is also associated with hair loss (the so-called colour dilution alopecia, CDA) and black hair follicular dysplasia (BHFD).
The E-Locus is a region of your dog's DNA which controls whether your dog will only contain the yellow pigment or whether they can be any of the other coat colours.
Like the A-Locus, there is a dominance hierarchy in the alleles (a.k.a. mutations) in the E-Locus:
Em > E > e
The Em allele is dominant and your dog only requires one copy of this allele to have a melanistic mask (darker muzzle). If your dog has a melanistic mask then they also have the coat colour described by the other regions (K-Locus, A-Locus, D-Locus and B-Locus).
If your dog has one copy of either Em or E then their coat colour is decided by the alleles they have at the K-Locus, A-Locus, D-Locus and B-Locus.
If your dog has two copies of the recessive allele (ee) then they will have a yellow coat, such as the coat colour seen in Golden Retrievers.
- Newton JM, Wilkie AL, Jordan SA, Metallinos DL, Holmes NG Jackson IJ and Barsh GS (2000) Melanocortin 1 receptor variation in the domestic dog. Mamm. Genome 11, 24-30
- Schmutz SM and Berryere TG (2007) Genes affecting coat colour and pattern in domestic dogs: a review. Anim. Genet. 38, 539-549.
- Schmutz SM, Berryere TG, Ellinwood NM, Kerns JA and Barsh GS (2003) MC1R Studies in Dogs with Melanistic Mask or Brindle patterns. J. Hered 94, 69-73
The K-Locus is a region of your dog's DNA which controls whether your dog has a black coat colour.
The K-Locus has three alleles with an order of dominance:
Black (KB) > brindle (kbr) > yellow (ky)
In the vast majority of dog breeds, a dog will need to have at least one of the E or Em allele and at least one KB allele to have a solid coat colour (black, brown or dilute).
If your dog has at least one copy of KB then their coat colour will be black, brown or dilute. If your dog has two copies of the ky allele (ky/ky) then their coat colour will be determined by the A-Locus.
The brindle allele doesn't have a DNA test yet as we scientists haven't yet discovered the exact DNA mutation that causes a brindle coat colour. Brindle occurs all over the coat in dogs with an ay allele (A-Locus) but only the ventral (stomach) surface in dogs with an at/at result at the A-Locus.
- Berryere TG, Kerns JA, Barsh GS, Schmutz SM (2005). Association of an Agouti allele with fawn or sable coat colour in domestic dogs. Mamm. Genome 16, 262-272
- Kerns JA, Cargill EJ, Clark LA, Candille SI, Berryere TG, Olivier M, Lust G, Todhunter RJ, Schmutz SM, Murphy KE et al (2007). Linkage and Segregation Analysis of black and brindle coat colour in domestic dogs. Genetics 176, 1679-1689.
This coat colour is only applicable to Great Danes and, in combination with the M-Locus (Merle), produces a harlequin coat colour pattern.
The M-Locus is the region of your dog's DNA which produces a merle patterning in the coat. Our Merle test will confirm the presence of Merle patterning but does not report the amount of dilution based on oligo(dT).
The S-Locus is a region of your dog's DNA which determines whether they will have any patches of white spotting or a largely white coat. The white coat is caused by hairs which lack both the phaeomelanin pigment and the eumelanin pigment.
The gene involved in the S-Locus regulates the control of coat colour pigmentation.
There are two main alleles which have been described:
S (no white, solid colour) and s (piebald, pied, white spotting).
There are several mutations in the S-Locus and we only test for the most common. Mutations in the S-Locus have also been implicated in disorders of the eye and hearing.
- Karlsson EK, Baranowska I, Wade CM, Salmon Hillbertz NH et al (2007) Efficient mapping of mendelian traits in dogs through genome-wide association. Nat. Genet. 39(11):1321-8
- Schmutz SM (2009) MITF and white spotting in dogs: a population study. J. Hered 100 (S1): S66-S74
- Baranowska Korberg I, Sundstrom E, Meadows JRS, Rosengren Pielberg G et al (2014) A simple repeat polymorphism in the MITF-M promoter is a key regulator of white spotting in dogs. PLoS ONE 9(8): e104363
Saddle Tan is an additional colour within the A-Locus but it only applies to Basset Hound and Pembroke Welsh Corgis. It is a modifier of the A-Locus black and tan points (at) allele. In order for the Saddle Tan colour to be present in a dogs coat they must be at/at at the A-Locus.
The Saddle Tan modifier causes the black coat colour on a black and tan dog to retreat to the dog's back, while the rest of the coat will be red. The red coat will extend over the whole head, the front of the chest and neck and the top of the legs, while black will remain only on the back, tail and the back of the neck. Saddle tan dogs are usually born as black and tan, but the black areas reduce as the dog ages.
The T-Locus is a region of your dog's DNA which determines whether they have a naturally short bobtail or not. The locus is named after the gene where the mutation causing the short bobtail is found (it's imaginatively called 'T', or 'tailless').
We report the test results for this test as 'Long' or 'Short'.
Your dog only needs to carry one copy of the furnishings allele to have a wire haired coat and the extra fur around their eyebrows and muzzle (facial furnishings).
We report these results as either F/F (two copies of furnishings), F/N (one copy of furnishings, or N/N (no copies of furnishings.
Curly coat in dogs covers a range of breeds that can be difficult to classify. The differences between breeds range from the long, straight hair of the Afghan Hound to the long, tight curls of the Poodle.
The Cu-locus is the region of your dog's DNA which determines whether their coat will be curly or not. The curly coat is a recessive trait, which means that two copies of the Cu allele must be present for a dog to have curly fur (Cu/Cu in our results).
The L-Locus is the region of your dog's DNA which controls whether they will have long hair, like a Golden Retriever, or short hair, like a Labrador Retriever. Our test can determine long hair in all breeds apart from the Yorkshire Terrier.
The SD-Locus is the region of your dog's DNA which controls how much fur they shed. It is somewhat of a sliding scale, but we report these results as:
- Low (example: Poodle)
- High (example: Siberian Husky)