Foresight Health® Canine Leucocyte Adhesion Deficiency

Our Foresight Health® single test for Canine Leucocyte Adhesion Deficiency is ideal for breeders and owners who want the reassurance of genetic health testing.

The guideline turnaround time for single tests is approximately 10-12 working days after the swab arrives at the lab.

If you need more than two tests it is often more cost-effective to order the relevant Foresight Health^® breed package.

Description

Canine Leucocyte Adhesion Deficiency (CLAD) is a blood disorder affecting the platelets and white blood cells. In Type I white blood cells cannot fight infection and affected dogs usually suffer fatally from severe infections. Onset is usually less than 12 weeks of age. Type III is characterised by prolonged bleeding and chronic infections. Affected dogs can survive for years but are susceptible to severe bleeding with injury or surgery.

Canine Leucocyte Adhesion Deficiency is an autosomal recessive condition caused by a mutation in the ITGB2 (Type 1) or FERMT3 (Type 3) gene.

Breeds

This test is also included in the following Foresight Health^® breed packages:

• German Shepherd  (Type 3)
• Irish Doodle  (Type 1)
• Irish Red & White Setter  (Type 1)
• Irish Setter  (Type 1)

Scientific references:

Verfaillie T, Verdonck F, Cox E. Simple PCR-based test for the detection of canine leucocyte adhesion deficiency. Vet Rec. 2004 Jun 26;154(26):821-3

Kijas JM, Bauer TR Jr, Gäfvert S, Marklund S, Trowald-Wigh G, Johannisson A, Hedhammar A, Binns M, Juneja RK, Hickstein DD, Andersson L. A missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency. Genomics. 1999 Oct 1;61(1):101-7

Hugo TB, Heading KL. Leucocyte adhesion deficiency III in a mixed-breed dog. Aust Vet J. 2014 Aug;92(8):299-302.